Novel electrospun implants of Sunitinib can depress ex-vivo ocular neovascularization

Ex Vivo Expansion of Umbilical Cord Blood Hematopoietic Stem Cells on Collagen- Fibronectin Coated Electrospun Nano Scaffold

Background and Objective: Umbilical Cord blood (UCB) hematopoietic stem cell (HSC) transplantation is a therapeutic approach for the treatment of malignant and non-malignant hematologic disorders due to ease of collection, lack of risk for donors and lower levels of infection. Moreover, it is considered a good alternative for bone marrow HSC transplantation. The main limitation of their use is ...

Ocular Neovascularization Caused by Herpes

A novel in vivo model of puncture-induced iris neovascularization

PURPOSE To assess iris neovascularization by uveal puncture of the mouse eye and determine the role of angiogenic factors during iris neovascularization. METHODS Uveal punctures were performed on BalbC mouse eyes to induce iris angiogenesis. VEGF-blockage was used as an anti-angiogenic treatment, while normoxia- and hypoxia-conditioned media from retinal pigment epithelium (RPE) cells was use...

Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization.

Animal studies and preliminary results in humans suggest that lower extremity and myocardial ischemia can be attenuated by treatment with angiogenic cytokines. The resident population of endothelial cells that is competent to respond to an available level of angiogenic growth factors, however, may potentially limit the extent to which cytokine supplementation enhances tissue neovascularization....

A novel ex vivo model of equine corneal wound healing

Corneal disease is a significant cause of decreased vision or blindness in the horse worldwide. Numerous topical and systemic drugs over a prolonged period of time may be used to treat an equine corneal ulcer. Despite the high prevalence of corneal disease and ulceration in the horse, and the complexity of corneal wound healing, research is limited and more heavily devoted to in vivo studies wh...